Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A case of multiple type I endocrine neoplasia with gastrin-producing and glucagon-producing tumors successfully resected 18 years after insulinoma surgery.

Clinical journal of gastroenterology·2026
Same author

Long-term survival after multidisciplinary treatment including durvalumab for recurrent perihilar cholangiocarcinoma.

Clinical journal of gastroenterology·2026
Same author

Current Status and Future Applications of Robotic Surgery in Upper Gastrointestinal Surgery: A Narrative Review.

Cancers·2025
Same author

Fistula closure technique using an esophageal stent and fixation method for gastrointestinal-airway fistula after esophageal cancer surgery.

Esophagus : official journal of the Japan Esophageal Society·2025
Same author

[Splenic Sarcoidosis with Concurrent Gastric Cancer Diagnosed by Robot-Assisted Surgery-A Case Report].

Gan to kagaku ryoho. Cancer & chemotherapy·2025
Same author

Usefulness of Perioperative Nutritional Therapy with the Glutamine/Arginine/Calcium β-Hydroxy-β-Methylbutyrate Product in Esophageal Cancer Surgery: A Single-Center Retrospective Study.

Nutrients·2024

Related Experiment Video

Updated: May 21, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Splicing in oncogenesis and tumor suppression.

Daisuke Kaida1, Tilman Schneider-Poetsch, Minoru Yoshida

  • 1Frontier Research Core for Life Sciences, University of Toyama, Japan.

Cancer Science
|June 14, 2012
PubMed
Summary

Aberrant messenger RNA (mRNA) splicing is implicated in cancer development. Small molecules targeting splicing offer a promising avenue for novel cancer therapies.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • RNA Biology

Background:

  • Post-transcriptional modifications, including 5' capping, 3' polyadenylation, and splicing, are crucial for gene expression regulation and transcriptome stability.
  • Dysregulation of these RNA processing events, particularly splicing, is frequently observed in cancer cells and contributes to disease pathogenesis.

Purpose of the Study:

  • To review the mechanisms by which alterations in RNA splicing regulatory elements or mutations in splicing factors lead to altered expression of oncogenes and tumor suppressors.
  • To explore the potential of small molecules that modulate splicing activity as a therapeutic strategy for cancer treatment.

Main Methods:

  • Review of existing literature on RNA splicing, cancer, and small molecule therapeutics.
  • Analysis of how changes in splicing impact oncogene and tumor suppressor expression.

More Related Videos

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Related Experiment Videos

Last Updated: May 21, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

  • Examination of the anticancer activity of small molecules targeting spliceosomal components and splicing regulators.

    • Main Results:

    • Alterations in RNA splicing regulatory elements or mutations in splicing factors can pathologically affect the expression of key cancer-related genes.
    • Several small molecules have demonstrated the ability to inhibit or modulate splicing activity by interacting with spliceosomal components and splicing regulators.

    Conclusions:

    • Aberrant mRNA splicing is a significant factor in cancer development.
    • Small molecule modulators of splicing exhibit anticancer activity and represent a promising area for next-generation cancer therapeutics.