[Inhibition of caries by Na-saccharin]

The inhibition of dental caries by Na-saccharin was studied in an optimized and standardized experiment with cara rats. The animals were given a cariogenic diet ad libitum as well as under controlled frequency feeding conditions. The addition of 0.5% Na-saccharin to the cariogenic diet produced no cariostatic effects. Ancilliary microbiological in vitro and in vivo experiments showed no appreciable bacteriostatic effects on the cariogenic bacteria flora.