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Acute Pyelonephritis II: Diagnostic Studies and Management

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Updated: May 21, 2026

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Daptomycin therapy for osteomyelitis: a retrospective study.

Jason C Gallagher¹, Jennifer A Huntington, Darren Culshaw

¹School of Pharmacy, Temple University, 3307 N Broad St, Philadelphia, PA19140, USA.

BMC Infectious Diseases

|June 14, 2012

Summary

This summary is machine-generated.

Daptomycin effectively treated osteomyelitis in a study of 209 patients, showing a 94% clinical resolution rate. This antibiotic demonstrated an acceptable safety profile for Gram-positive infections, including Staphylococcus aureus.

Related Experiment Videos

Last Updated: May 21, 2026

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Area of Science:

Infectious Diseases
Pharmacology
Clinical Medicine

Background:

Osteomyelitis is frequently caused by Gram-positive organisms, notably Staphylococcus aureus.
Daptomycin is a potent bactericidal agent effective against Gram-positive pathogens.

Purpose of the Study:

To evaluate the clinical outcomes of daptomycin treatment for non-hardware associated osteomyelitis.
To assess the safety profile of daptomycin in managing these infections.

Main Methods:

Retrospective, multicenter, observational registry of osteomyelitis patients treated with daptomycin (2007-2008).
Exclusion of patients with concurrent orthopedic foreign body infections.
Assessment of patient outcomes (cured, improved, failed) and safety analysis.

Main Results:

94% of patients achieved clinical resolution after daptomycin therapy.
Approximately 85% maintained successful outcomes at re-evaluation.
18% of patients experienced adverse events possibly related to daptomycin.

Conclusions:

Daptomycin is an effective treatment option for osteomyelitis not involving hardware.
Daptomycin exhibits an acceptable safety profile for this indication.