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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Neuroreceptor imaging in depression.

Jonathan B Savitz1, Wayne C Drevets

  • 1Laureate Institute for Brain Research, Tulsa, OK 74136, USA. jonathansavitz@hotmail.com

Neurobiology of Disease
|June 14, 2012
PubMed
Summary
This summary is machine-generated.

Positron emission tomography (PET) studies reveal altered neuroreceptor function in major depressive disorder (MDD) and bipolar disorder (BD). This review examines serotonin and dopamine system receptors, transporters, and enzymes implicated in mood disorders.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Mood disorders like major depressive disorder (MDD) and bipolar disorder (BD) significantly impact global health.
  • Understanding the neurobiological underpinnings of these disorders is crucial for developing effective treatments.

Purpose of the Study:

  • To review positron emission tomography (PET) studies investigating neuroreceptor binding potential in the human brain in mood disorders.
  • To focus on key receptors within the serotonergic and dopaminergic systems, as well as related transporters and enzymes.

Main Methods:

  • Comprehensive review of existing PET imaging literature on neuroreceptor function in MDD and BD.
  • Integration of findings with supporting genetic studies, postmortem data, and preclinical models.

Main Results:

  • PET studies have identified alterations in specific serotonin receptors (5-HT1A, 5-HT2A, 5-HT1B), dopamine receptors (D1, D2/3), transporters (5-HTT, DAT), and enzymes (MAO-A) in mood disorders.
  • Evidence suggests dysregulation in monoaminergic systems is a key feature of MDD and BD.

Conclusions:

  • PET imaging provides valuable in vivo insights into the neurobiology of mood disorders.
  • Altered monoaminergic function, influenced by factors like inflammation and endocrine dysfunction, plays a significant role in the pathophysiology of depression and bipolar disorder.