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Updated: May 21, 2026

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
Published on: December 30, 2025
Total face, double jaw, and tongue transplant simulation: a cadaveric study using computer-assisted techniques.
Emile N Brown1, Amir H Dorafshar, Branko Bojovic
1Baltimore, Md. From the Division of Plastic Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine.
This study evaluates a new, highly complex face and tongue transplant procedure using digital planning and real-time surgical navigation. By testing this approach on cadavers, researchers demonstrated that computer-assisted tools allow for highly accurate bone alignment and facial reconstruction, significantly reducing the need for manual adjustments during surgery.
Area of Science:
- Reconstructive surgery outcomes research within vascularized composite allograft medicine
- Advanced craniofacial imaging and surgical planning techniques
Background:
No prior work had resolved the technical challenges of performing total face and tongue transplants with high anatomical precision. Surgeons often struggle to maintain proper skeletal alignment during such extensive facial reconstructive procedures. Prior research has shown that vascularized composite allografts require meticulous planning to achieve aesthetic and functional success. That uncertainty drove the need for advanced digital tools to guide complex bone cuts. It was already known that traditional methods often lead to unpredictable outcomes in large-scale facial tissue transfers. This gap motivated the exploration of computer-assisted planning for these specific, demanding surgeries. Researchers recognized that integrating navigation systems might enhance the reliability of bone fixation. Such innovations are necessary to improve patient outcomes in cases involving severe central facial demolition.
Purpose Of The Study:
The study aims to evaluate the effectiveness of computer-assisted planning and navigation in performing total face and tongue transplants. Researchers sought to determine if digital tools could improve the precision of complex bone cuts. This investigation addresses the challenge of achieving accurate skeletal alignment in extensive facial tissue transfers. The authors were motivated by the need to standardize procedures for severe central facial demolition. They hypothesized that virtual modeling would reduce the necessity for manual adjustments during the operation. By simulating these procedures on cadavers, the team explored the feasibility of integrating advanced technology into reconstructive workflows. The project specifically examines the accuracy of Le Fort III and sagittal split osteotomies under guided conditions. This work provides a foundation for applying digital precision to demanding reconstructive surgical tasks.
Main Methods:
The research team conducted ten mock transplants using twenty cadaveric specimens to simulate extensive facial reconstruction. They utilized preoperative computed tomographic scans to generate high-resolution three-dimensional models of the donor and recipient anatomy. Surgical planning software allowed the investigators to virtually simulate the necessary midface and mandibular bone cuts. During the procedure, a navigation system provided real-time guidance to ensure the accuracy of these osteotomies. The investigators performed Le Fort III and sagittal split osteotomies to prepare the skeletal structures for transplantation. They compared the virtual surgical plan against the actual postoperative skeletal results using cephalometric analysis. This approach focused on achieving optimal donor-recipient bone matching and functional occlusion. The study design prioritized the evaluation of digital tools in reducing manual intraoperative modifications.
Main Results:
The combined use of digital planning and navigation consistently produced grafts that required only minimal bone burring for fixation. Postoperative computed tomography confirmed that the skeletal alignment was highly accurate across all ten mock procedures. Cephalometric comparisons between predicted and actual results showed insignificant differences, indicating high reliability of the virtual planning. The surgeons successfully maintained proper occlusion throughout the entire transplant process. This study represents one of the most extensive facial graft models described in the literature to date. The integration of these technologies greatly reduced the need for manual adjustments or complex intraoperative manipulation. The findings demonstrate that the donor-recipient skeletal match was consistently achieved through the guided approach. These results confirm that the proposed workflow effectively supports the demands of complex central facial demolition repair.
Conclusions:
The authors propose that digital planning and navigation systems enable consistent execution of extensive facial transplants. This synthesis suggests that combining these technologies facilitates accurate skeletal matching between donors and recipients. The findings imply that such workflows reduce the requirement for intraoperative bone adjustments. Reviewing the evidence, the researchers highlight that proper occlusion remains achievable through these guided methods. The study demonstrates that virtual modeling effectively predicts final postoperative skeletal positioning. These results support the adoption of computer-assisted workflows for complex reconstructive cases. The authors conclude that their approach provides a robust framework for managing severe facial injury patterns. Future applications of these techniques may improve the precision of large-scale tissue transfers in clinical settings.
Frequently Asked Questions
The researchers utilized a combination of preoperative digital planning and real-time intraoperative navigation. This dual approach allowed for precise execution of Le Fort III and sagittal split osteotomies, ensuring that the donor tissue aligned accurately with the recipient's skeletal structure.
The team employed specialized surgical planning software alongside computed tomographic scans. These digital tools enabled the creation of virtual models to guide the complex bone cuts required for the total face and tongue graft.
The authors state that the Le Fort III osteotomy and sagittal split osteotomies were required to properly position the midface and mandible. These specific bone cuts were essential to maintain functional occlusion and achieve a stable skeletal match.
Cephalometric analyses served as the primary data type to compare virtual predictions with actual postoperative results. This quantitative measurement confirmed that the skeletal fixation achieved during the mock transplants matched the initial digital plan with minimal deviation.
The study measured the degree of skeletal alignment and the necessity for manual bone burring. The researchers observed that the guided approach resulted in minimal need for post-cut adjustments, confirming the efficacy of the navigation system.
The authors propose that their methodology ensures a high level of precision for extensive facial grafts. They claim that this workflow effectively minimizes intraoperative manipulation, thereby improving the overall efficiency of complex reconstructive surgeries.

