Related Experiment Video
Updated: May 21, 2026

09:57
Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
Published on: September 20, 2024
A gut feeling about insular seizures.
S Dionisio1, A Koenig, J Murray
1Comprehensive Epilepsy Service, Prince of Wales Hospital, Randwick, Sydney, New South Wales, Australia. sashd1@gmail.com
BMJ Case Reports
|June 14, 2012
Summary
This study reports a case of focal seizures presenting as gagging episodes. Successful treatment with antiepileptic drugs highlights the importance of accurate diagnosis for seizure management.
Area of Science:
- Neurology
- Epileptology
- Neuroimaging
Background:
- Focal seizures can manifest with varied and sometimes subtle symptoms, challenging initial diagnosis.
- Gastrointestinal symptoms like gagging can be misattributed, delaying neurological evaluation.
Observation:
- A 43-year-old male presented with gagging, hypersalivation, and lachrymation episodes over two years.
- Electroencephalography (EEG) indicated right anterior temporal epileptiform discharges.
- Magnetic Resonance Imaging (MRI) identified a lesion in the right insular cortex.
Findings:
- Video-EEG telemetry confirmed the gagging episodes as focal seizures originating from the right insular cortex.
- The patient experienced no further seizures after initiating antiepileptic drug therapy.
Implications:
- This case underscores the necessity of considering focal epilepsy in patients with unexplained autonomic and gagging symptoms.
- Accurate localization using EEG and MRI is crucial for effective treatment of refractory epilepsy.
- Prompt diagnosis and appropriate antiepileptic drug management can significantly improve patient outcomes and quality of life.
Related Concept Videos
Seizures l: Introduction
Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Seizures ll: Types
Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
Seizures: Classification
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy ll: Types
Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Epilepsy and Seizures: Overview
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Major Somatic Sensory Pathways
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
