Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elastic Deformation of Optical Coherence Tomography Images of Diabetic Macular Edema for Deep-Learning Models Training: How Far to Go?

IEEE journal of translational engineering in health and medicine·2023
Same author

Automated 4-dimensional regional myocardial strain evaluation using cardiac computed tomography.

The international journal of cardiovascular imaging·2019
Same author

Strain analysis from 4-D cardiac CT image data.

IEEE transactions on bio-medical engineering·2014
See all related articles

Related Experiment Video

Updated: May 21, 2026

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

A neural network technique for remeshing of bone microstructure.

Anath Fischer1, Yaron Holdstein

  • 1Laboratory for CAD & LCE, Department of Mechanical Engineering, Technion-Israel Institute of Technology, Haifa, Israel. meranath@technion.ac.il

Methods in Molecular Biology (Clifton, N.J.)
|June 14, 2012
PubMed
Summary

This article presents a new computational approach using a specialized neural network to improve the quality of 3D bone models. By refining complex bone structures, this method enables more accurate analysis and manufacturing compared to standard commercial tools.

Keywords:
geometric modelingartificial intelligencecomputational biomechanics3D reconstruction

Frequently Asked Questions

More Related Videos

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Related Experiment Videos

Last Updated: May 21, 2026

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
06:51

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Area of Science:

  • Biomedical engineering research involving neural network remeshing techniques
  • Computational biomechanics and skeletal imaging analysis

Background:

Current clinical practices struggle to accurately evaluate complex skeletal architectures using standard noninvasive imaging. While high-resolution scanners now provide detailed volumetric data, transforming these images into usable digital models remains a significant challenge. Prior research has shown that existing commercial software often produces low-quality meshes unsuitable for advanced biomechanical simulation. That uncertainty drove the need for more robust geometric processing tools capable of handling intricate biological surfaces. No prior work had resolved the persistent issues of neighborhood ambiguity near vertices in highly porous bone samples. This gap motivated the exploration of artificial intelligence algorithms to automate the reconstruction process. Researchers have increasingly turned toward machine learning to overcome limitations inherent in traditional geometric modeling approaches. These developments highlight a shift toward automated, high-fidelity digital representations of internal anatomy.

Purpose Of The Study:

The primary aim of this study is to develop an accurate, noninvasive technique for the evaluation of bone microstructure using advanced computational methods. Researchers seek to address the limitations of current commercial systems that produce low-quality meshes for 3D bone reconstruction. The motivation stems from the increasing need for high-fidelity models in biomechanical analysis and rapid prototyping. Complex bone features often cause significant neighborhood ambiguity near vertices, which hinders the accuracy of standard digital representations. This project investigates whether a neural network approach can effectively remesh triangular manifold structures. The authors intend to demonstrate that their method functions without requiring prior knowledge regarding the original object's topology. By extending the growing neural gas algorithm, they aim to provide a more robust tool for skeletal imaging. This work addresses the urgent requirement for better geometric processing in the biomedical community.

Main Methods:

The review approach focuses on the application of a growing neural gas algorithm to refine 3D geometric data. Investigators utilize a computational framework where interconnected neurons perform independent arithmetic operations to map surface features. The study design involves testing the algorithm on triangular manifold meshes that simulate complex skeletal geometries. Researchers implement this system to resolve vertex ambiguity by allowing neurons to interact with their immediate neighbors. This approach avoids the need for predefined topological information or specific shape templates during the reconstruction phase. The methodology emphasizes an autonomous adaptation process that mimics artificial intelligence learning patterns. By applying this technique, the team aims to generate high-quality models suitable for engineering analysis. The process ensures that the resulting digital representations maintain structural integrity despite the intricate nature of the input specimens.

Main Results:

Key findings from the literature indicate that the growing neural gas technique successfully reconstructs genus-n freeform objects without requiring prior knowledge of the original specimen. The algorithm effectively addresses the neighborhood ambiguity near vertices that typically plagues standard commercial reconstruction tools. Results demonstrate that the neural network approach creates high-quality meshes suitable for both rapid prototyping and structural analysis. The authors report that the method functions autonomously, with each neuron calculating its position based on the influence of surrounding network elements. This technique provides a significant improvement over traditional 2D assessment methods by enabling accurate 3D evaluation of skeletal features. The data suggest that the model handles complex microstructural geometries with higher fidelity than existing commercial systems. The findings show that the network architecture is capable of mapping intricate surfaces through iterative arithmetic adjustments. This advancement provides a robust solution for generating accurate digital bone models from high-resolution imaging data.

Conclusions:

The proposed extension of the growing neural gas algorithm successfully reconstructs complex manifold surfaces without requiring prior topological information. This synthesis suggests that artificial intelligence offers a viable path for enhancing the quality of digital skeletal models. The authors demonstrate that their approach functions effectively for objects with arbitrary genus-n geometries. These findings imply that automated remeshing can overcome the limitations of commercial systems currently used in biomedical imaging. The study confirms that the network architecture adapts to intricate microstructural features autonomously during the reconstruction phase. This work provides a framework for future applications in rapid prototyping and structural analysis of bone. The evidence indicates that the technique maintains surface accuracy while reducing the computational burden of manual mesh correction. Ultimately, this approach represents a meaningful advancement in the digital representation of complex biological specimens.

The researchers propose an extension of the growing neural gas algorithm. This mechanism functions by utilizing interconnected neurons that perform autonomous arithmetic calculations, allowing the network to adapt to the surface of a genus-n object without needing prior knowledge of its specific shape or topology.

The authors utilize a triangular manifold mesh to represent the complex geometry of bone. This specific data structure is necessary because it allows the algorithm to accurately map the surface of intricate, porous biological specimens during the remeshing process.

A triangular manifold mesh is required because it provides a consistent geometric framework for the neural network to operate upon. Without this specific topology, the algorithm would struggle to resolve the neighborhood ambiguity that typically occurs near vertices in highly complex bone samples.

The neural network acts as the primary computational engine for the reconstruction process. It processes the input data through interconnected neurons, which influence one another to refine the mesh quality, effectively replacing less accurate commercial software outputs.

The researchers evaluate the success of their method by its ability to reconstruct the surface of a genus-n freeform object. This phenomenon confirms that the algorithm can handle complex, non-standard shapes without requiring a priori information about the original specimen.

The authors propose that this method enables more accurate analysis and rapid prototyping of bone models. By improving mesh quality, the technique allows for better biomechanical evaluation and physical manufacturing of complex skeletal structures compared to current commercial standards.