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Updated: May 21, 2026

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

Drug-associated blood cell dyscrasias.

Douglas J Weiss¹

¹University of Minnesota, MN, USA.

Compendium (Yardley, PA)

|June 14, 2012

Summary

Many drugs cause hematologic adverse drug events (ADEs) in animals through bone marrow suppression or immune-mediated destruction. Periodic blood counts are crucial for monitoring drugs like chemotherapy agents and phenylbutazone.

Area of Science:

Veterinary Pharmacology
Toxicology
Hematology

Background:

Therapeutic drugs can cause significant hematologic adverse drug events (ADEs) in animals.
These ADEs can range from dose-dependent bone marrow suppression to idiosyncratic reactions.

Purpose of the Study:

To review the mechanisms and drug classes associated with hematologic ADEs in animals.
To highlight the importance of monitoring specific drugs known to frequently cause these events.

Main Methods:

Literature review of known drug-induced hematologic adverse events in veterinary medicine.
Categorization of drugs based on mechanisms of action (e.g., chemotherapy, oxidants) and reaction types (dose-dependent vs. idiosyncratic).

Main Results:

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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

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Real-time Cytotoxicity Assays in Human Whole Blood

Real-time Cytotoxicity Assays in Human Whole Blood

Published on: November 7, 2014

Hematologic ADEs result from bone marrow suppression, immune-mediated destruction, or oxidant-mediated damage.
Idiosyncratic ADEs can be induced by various drug classes including NSAIDs, antibiotics, and antithyroid drugs.
Chemotherapeutic agents and specific drugs like phenylbutazone and phenobarbital frequently cause ADEs requiring monitoring.

Conclusions:

Understanding drug-induced hematologic ADEs is critical for animal health.
Periodic complete blood counts are essential for early detection and management of ADEs associated with frequently implicated drugs.