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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

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Related Experiment Video

Updated: May 21, 2026

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

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The Notch pathway in hematopoietic stem cells.

Anna Bigas1, Teresa D'Altri, Lluis Espinosa

  • 1Program in Cancer Research. Institut Mar Investigacions Mèdiques (IMIM), Hospital del Mar, Parc de Recerca Biomèdica de Barcelona, Dr. Aiguader 88, 08003, Barcelona, Spain. abigas@imim.es

Current Topics in Microbiology and Immunology
|June 14, 2012
PubMed
Summary
This summary is machine-generated.

Hematopoietic Stem Cells (HSCs) generate blood cells and rely on self-renewal. The Notch pathway plays a critical role in HSC establishment and maintaining their stem-cell properties during development.

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

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Last Updated: May 21, 2026

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Area of Science:

  • Developmental biology
  • Hematology
  • Cell signaling

Background:

  • Hematopoiesis generates all blood cell types from Hematopoietic Stem Cells (HSCs).
  • HSCs possess self-renewal and pluripotency, crucial for lifelong blood production.
  • The precise mechanisms governing HSC self-renewal and pluripotency remain incompletely understood.

Purpose of the Study:

  • To review the established and emerging roles of the Notch signaling pathway in Hematopoietic Stem Cell (HSC) generation.
  • To elucidate Notch's function in maintaining HSC self-renewal and pluripotency.
  • To explore Notch's involvement in hematopoietic cell lineage specification.

Main Methods:

  • Literature review of studies on Notch signaling in hematopoiesis.
  • Analysis of experimental data linking Notch to HSC establishment and differentiation.
  • Synthesis of current knowledge on Notch's dual role in stem cell maintenance and cell fate decisions.

Main Results:

  • The Notch pathway is essential for the initial generation and establishment of HSCs during embryonic development.
  • Notch signaling influences HSC self-renewal, with context-dependent effects on differentiation.
  • Specific Notch interactions dictate cell fate decisions within hematopoietic lineages.

Conclusions:

  • The Notch pathway is a key regulator of Hematopoietic Stem Cell (HSC) biology.
  • Understanding Notch signaling is critical for deciphering HSC self-renewal and pluripotency.
  • Targeting Notch may offer therapeutic avenues for hematopoietic disorders.