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Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

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Related Experiment Video

Updated: May 21, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Notch signaling during human T cell development.

Tom Taghon¹, Els Waegemans, Inge Van de Walle

¹Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium. tom.taghon@ugent.be

Current Topics in Microbiology and Immunology

|June 14, 2012

Summary

Notch signaling is vital for human T cell development, with distinct roles compared to mice. This review details Notch pathway activation and function throughout human T-cell differentiation.

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Last Updated: May 21, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia

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Published on: June 9, 2023

Area of Science:

Immunology
Developmental Biology
Molecular Biology

Background:

Notch signaling is essential for T cell development in both humans and mice.
Emerging evidence suggests species-specific differences in how Notch regulates T-lineage differentiation.
Understanding these differences is crucial for comprehending human immune system development.

Purpose of the Study:

To review the current understanding of Notch signaling during human T cell development.
To describe the developmental stages of human T cells.
To analyze Notch receptor, ligand, and target gene expression profiles throughout this process.

Main Methods:

Review of existing literature on human T cell development.
Analysis of expression profiles of Notch pathway components (receptors, ligands, target genes).
Interpretation of functional studies on Notch signaling in human T cell development.
Comparative analysis with Notch signaling roles in mouse T cell development.

Main Results:

Detailed description of human T cell developmental stages.
Characterization of Notch pathway component expression patterns during T cell development.
Interpretation of stage-specific functions of Notch signaling based on expression data and functional studies.
Highlighting key differences in Notch-mediated T cell development between humans and mice.

Conclusions:

Notch signaling plays a critical, stage-specific role in human T cell development.
The precise mechanisms and outcomes of Notch signaling differ between human and mouse T cell development.
Further research is needed to fully elucidate species-specific Notch pathway functions in T-lineage commitment and differentiation.