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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
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Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
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Published on: January 14, 2021

Pattern formation during vasculogenesis.

Andras Czirok1, Charles D Little

  • 1Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA. aczirok@kumc.edu

Birth Defects Research. Part C, Embryo Today : Reviews
|June 14, 2012
PubMed
Summary
This summary is machine-generated.

Vasculogenesis, the formation of the first vascular network, is crucial for embryonic development. Understanding its cellular and molecular mechanisms, including contact guidance and chemotaxis, is key to explaining vascular patterning.

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Area of Science:

  • Developmental Biology
  • Biophysics
  • Cell Biology

Background:

  • Vasculogenesis is the embryonic assembly of the primary vascular network, forming the first organ system.
  • Understanding vascular patterning is essential for both developmental biology and regenerative medicine.

Purpose of the Study:

  • To explore the organizational principles governing vascular network formation.
  • To bridge the gap between cellular behaviors and macroscopic vascular patterns.

Main Methods:

  • Review of proposed hypotheses for vascular pattern formation.
  • Discussion of mathematical analyses and computer simulations for conceptualizing developmental processes.

Main Results:

  • Identified key proposed mechanisms for vascular pattern formation: contact guidance, chemotaxis, and sprouting.
  • Highlighted the role of cell behavior, guided by biochemical signals and cell-cell interactions.

Conclusions:

  • Cellular behaviors, modulated by biochemical signaling, dictate tissue-level morphogenesis in vasculogenesis.
  • Mathematical and computational approaches are valuable tools for testing hypotheses in vascular development.