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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

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Fluoxetine-induced pill oesophagitis.

Abdul Majid Wani¹, Abdul Gaffar Shiekh, Waleed M Hussain

¹Department of Medicine, Bahrain Specialist Hospital, Manama, Bahrain. dr_wani_majid@yahoo.co.in

BMJ Case Reports

|June 14, 2012

Summary

Pill-induced oesophagitis, a common esophageal condition, can be caused by various medications. This case highlights fluoxetine as a potential culprit in young adults without prior esophageal issues.

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Area of Science:

Gastroenterology
Pharmacology
Oesophagology

Background:

Pill-induced oesophagitis is a recognized adverse effect of numerous medications.
Commonly implicated drugs include antibiotics, cardiac medications, NSAIDs, and alendronate.
The condition affects individuals across a wide age range (3-98 years) with a female predominance (1.5:1 ratio).

Observation:

A case of oesophagitis was observed in a young adult patient.
The patient was taking fluoxetine, a selective serotonin reuptake inhibitor (SSRI).
No pre-existing oesophageal abnormalities were identified in the patient.

Findings:

Fluoxetine was identified as the causative agent for pill-induced oesophagitis in this young adult.
This represents a less commonly reported cause of drug-induced oesophageal injury.
The absence of underlying pathology underscores the direct role of the medication.

Implications:

Highlights the importance of considering fluoxetine in the differential diagnosis of pill-induced oesophagitis.
Suggests that SSRIs, beyond their psychiatric indications, may have gastrointestinal adverse effects.
Emphasizes the need for careful medication review in patients presenting with oesophageal symptoms.