Heat perfusion for malignancy

Hyperthermia, total anoxia and low pH have shown selective lethal effect on malignant cells. A perfusion system was devised to combine these modalities and was tried in 4 cases of advanced malignancy. A perfusion lasting for 45 minutes was found safe for normal tissue and yet selectively injurious to malignant cells. Technically this is a very simple procedure and its principles can be utilized in regional infusion also. Though the clinical material is scanty,the method deserves further trial.