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Related Experiment Videos

Largest phyllodes tumor- case report and brief review article.

Tarun Kumar, Mahesh D Patel, Rexeena Bhargavan

    Indian Journal of Surgical Oncology
    |June 14, 2012
    PubMed
    Summary

    This report details a 15kg borderline phyllodes tumor, the largest documented, and discusses radiotherapy's role in breast phyllodes tumor management. Further research is needed to clarify treatment efficacy.

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    Area of Science:

    • Oncology
    • Surgical Pathology

    Background:

    • Phyllodes tumors of the breast are rare fibroepithelial neoplasms with unpredictable behavior.
    • Malignant phyllodes tumors can recur and metastasize, necessitating aggressive treatment strategies.

    Observation:

    • A 32-year-old female presented with a recurrent right breast lump, diagnosed as a borderline phyllodes tumor.
    • The tumor measured an unprecedented 50 x 25.2 x 16.4 cm and weighed 15 kg.
    • Histopathological analysis revealed a borderline phyllodes tumor with low proliferation markers (Ki-67: 1-2%, p53: 3-4%).

    Findings:

    • Radical mastectomy with Latissimus Dorsi Myocutaneous flap reconstruction was performed as a curative measure.
    • The patient experienced an uneventful postoperative recovery and has been followed for one year.

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  • This case represents the largest phyllodes tumor reported in the literature.

    • Implications:

    • This case highlights the extreme end of phyllodes tumor presentation and the challenges in surgical management.
    • The role of adjuvant radiotherapy in borderline phyllodes tumors requires further investigation.
    • Understanding the behavior of giant phyllodes tumors is crucial for optimizing patient outcomes.