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Updated: May 21, 2026

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Altered velocity processing in schizophrenia during pursuit eye tracking.

Matthias Nagel1, Andreas Sprenger, Susanne Steinlechner

  • 1Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany. ma.nagel@asklepios.com

Plos One
|June 14, 2012
PubMed
Summary

Patients with schizophrenia exhibit impaired smooth pursuit eye movements (SPEM) due to altered neural activation in key brain regions. This suggests difficulties in processing visual motion for motor commands.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Psychiatry

Background:

  • Smooth pursuit eye movements (SPEM) are crucial for maintaining visual focus on moving objects.
  • Approximately 50-80% of individuals with schizophrenia experience deficits in SPEM.

Purpose of the Study:

  • To investigate neural underpinnings of SPEM deficits in schizophrenia using functional magnetic resonance imaging (fMRI).
  • To examine the impact of target velocity and internal guidance on SPEM-related brain activation in patients and controls.

Main Methods:

  • Event-related fMRI was used to measure brain activity in 17 patients with schizophrenia and 16 healthy controls.
  • Participants performed SPEM tasks at four velocities (5-20°/s) with and without visual target blanking intervals.
  • Eye movements were recorded, and statistical analyses included ANOVAs and regression analyses correlating Blood Oxygen Level Dependency (BOLD) signal with target velocity.

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Main Results:

  • Patients showed reduced activation in visual area V5 and putamen, but increased activation in cerebellar regions compared to controls.
  • Regression analyses revealed a lack of correlation between target velocity and activation in the supplementary eye field, putamen, and cerebellum in patients.
  • Activation in V5 and the intraparietal sulcus (LIP) showed weaker correlation with target velocity in patients than in controls.

Conclusions:

  • Altered neural activation patterns in the SPEM network (V5, SEF, LIP, putamen) suggest impaired visual motion to motor command transformation in schizophrenia.
  • Cerebellar regions may play a compensatory role, though their activity was not velocity-dependent in patients.