Related Experiment Video
Updated: May 21, 2026
Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
Published on: May 16, 2025
[Taurine induces apoptosis in pulmonary artery smooth muscle cells]
Xiaodan Zhang1, Jiejing Sheng, Caixiaz Zhang
1Harbin University of Commerce, Harbin 150076, China. zhangxd85@163.com
Objective:
To study the effect of taurine on apoptosis in PASMCs, and whether the death-receptor pathway act in the mechanism.
Method:
Culture the PASMCs, and divided the cells into control, SD. Acridine orange(AO) assay and western-blot analysis on the expression of Bax, Bcl-2, Procaspase-3 and Fas were used to study the mechanism.
Result:
A major finding of this study is that the Tau effects many apoptosis index, such as increasing the expression of Bax and Fas, decreasing the expression of Procaspase-3, and Bcl-2, accrescencing the mitochondrial depolarization, causing the nuclear shrinkage, all these datas demonstrated that Tau induced the apoptosis in pulmonary artery smooth muscle cells through mitochondrial-dependent pathway.
Conclusion:
Tau induces the apoptosis in pulmonary artery smooth muscle cells through death-receptor.
