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Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
Published on: December 15, 2023
Experience-dependent brain plasticity after stroke: effect of ibuprofen and poststroke delay
Jan A Jablonka1, Malgorzata Kossut, Otto W Witte
1Department of Animal Physiology, Faculty of Biology, Warsaw University, Warsaw, Poland.
The European Journal of Neuroscience
|June 15, 2012
Summary
Stroke impairs brain plasticity, hindering recovery. However, anti-inflammatory drugs like ibuprofen can restore this plasticity by reducing inflammation, offering potential therapeutic strategies for stroke patients.
Area of Science:
- Neuroscience
- Neuroplasticity
- Stroke Research
Background:
- Stroke can impact experience-dependent brain plasticity.
- Inflammation is a key factor following stroke.
- Understanding plasticity changes is crucial for recovery.
Purpose of the Study:
- To investigate the effect of stroke on experience-dependent plasticity in the rat cerebral cortex.
- To explore the role of inflammation in post-stroke plasticity impairment.
- To evaluate the potential of anti-inflammatory treatment to restore plasticity.
Main Methods:
- Photothrombotic stroke model in rats targeting the barrel cortex.
- Sensory deprivation of vibrissae to induce plasticity.
- [(14)C]-2-deoxyglucose autoradiography for visualization.
- Western blot analysis for cyclooxygenase-2 (COX-2) expression.
- Treatment with ibuprofen during sensory deprivation.
Main Results:
- Stroke impaired experience-dependent plasticity in the adjacent cortex.
- Delayed sensory deprivation partially restored plasticity.
- Stroke induced upregulation of cyclooxygenase-2 (COX-2).
- Ibuprofen treatment restored plasticity and prevented COX-2 upregulation.
Conclusions:
- Stroke-induced inflammation impairs cortical plasticity.
- Delayed inflammation resolution may allow partial plasticity recovery.
- Anti-inflammatory treatment with ibuprofen shows promise for restoring post-stroke plasticity.
