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Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Drugs for bone healing.

Maria Luisa Brandi1

  • 1University of Florence, Department of Surgery and Translational Medicine, Mineral and Bone Metabolic Diseases Unit, Largo Palagi, 1, 50100 Florence, Italy. m.brandi@dmi.unifi.it

Expert Opinion on Investigational Drugs
|June 15, 2012
PubMed
Summary
This summary is machine-generated.

Systemic drugs show promise for accelerating fracture healing, particularly in elderly osteoporotic patients. While current clinical use remains debated, ongoing trials may soon validate pharmacological agents as effective bone healers.

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Area of Science:

  • Orthopedics
  • Pharmacology
  • Regenerative Medicine

Background:

  • Fracture healing is a complex biological process influenced by patient factors, trauma, and fracture stability.
  • Complications in fracture healing significantly impact patient quality of life, especially in elderly osteoporotic individuals.

Purpose of the Study:

  • To review systemic pharmacological agents investigated for their efficacy in accelerating fracture healing.
  • To assess the current clinical evidence and ongoing trials for drugs targeting bone remodeling to enhance fracture repair.

Main Methods:

  • Conducted a literature search using terms like "drug or pharmacology of fracture healing."
  • Focused on reviewing clinical trials that have documented or are underway to assess the efficacy of systemic agents on bone healing.

Main Results:

  • Polytherapy combining growth factors, osteogenic cells, and osteoconductive factors has shown high success rates in bone regeneration.
  • Significant expectations exist for drugs targeting bone remodeling to efficiently accelerate fracture healing.

Conclusions:

  • The clinical application of systemic pharmacological agents to enhance fracture healing is currently controversial.
  • Future clinical trials are expected to provide data necessary for registering drugs as "healers" for bone fractures.