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Establishment of functional T cells in SCID mice does not lead to termination of pregnancy
C M Hetherington1, D W Dresser
1National Institute for Medical Research, London U.K.
Syngeneic (CB20) thymus and spleen T cells transferred to SCID mice, and shown to be present by flow cytometric analysis and functional by their ability to reject third-party skin grafts, do not lead to a detectable failure of syngeneic or allogeneic pregnancy. Unless the small number of B cells contaminating the T-cell innocula are capable of mounting a blocking antibody response, it is concluded that these results show that a humoral ('blocking antibody') response is not essential for successful pregnancy.
Syngeneic (CB20) thymus and spleen T cells transferred to SCID mice, and shown to be present by flow cytometric analysis and functional by their ability to reject third-party skin grafts, do not lead to a detectable failure of syngeneic or allogeneic pregnancy. Unless the small number of B cells contaminating the T-cell innocula are capable of mounting a blocking antibody response, it is concluded that these results show that a humoral ('blocking antibody') response is not essential for successful pregnancy.