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Short course chemotherapy (9 months) for lymphnode tuberculosis.

D Behera1, S K Jindal

  • 1Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.

The Indian Journal of Chest Diseases & Allied Sciences
|January 1, 1990
PubMed
Summary
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Nine months of anti-tubercular therapy for tubercular lymphadenitis using rifampicin, isoniazid, and ethambutol was insufficient. Extending treatment to one year improved outcomes, suggesting longer durations are necessary for effective gland clearance.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Pulmonology

Background:

  • Tubercular lymphadenitis is a common extrapulmonary manifestation of tuberculosis.
  • Standard treatment regimens require evaluation for optimal duration and efficacy.

Purpose of the Study:

  • To assess the efficacy of a 9-month treatment course for tubercular lymphadenitis.
  • To determine if extending therapy improves treatment outcomes.

Main Methods:

  • A study involving 82 patients diagnosed with tubercular lymphadenitis.
  • Treatment administered included rifampicin, isoniazid, and ethambutol.
  • Treatment duration was initially set at 9 months, with an extension to 1 year for some patients.

Main Results:

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  • After 9 months of therapy, complete gland disappearance was observed in only 74.3% of patients.
  • Extending treatment to 1 year resulted in clearance in an additional 10 cases.
  • The overall response rate after 1 year of therapy reached 87.2%.

Conclusions:

  • A 9-month therapeutic regimen with rifampicin, isoniazid, and ethambutol is not satisfactory for treating tubercular lymphadenitis.
  • Longer treatment durations, up to 1 year, demonstrate improved clearance rates.
  • Further investigation into optimal treatment durations for tubercular lymphadenitis is warranted.