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Related Concept Videos

Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

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Related Experiment Video

Updated: May 21, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

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Sutureless aortic valve replacement: first-year single-center experience.

Giuseppe Santarpino1, Steffen Pfeiffer, Joachim Schmidt

  • 1Department of Cardiac Surgery, Klinikum Nürnberg, Nuremberg, Germany. g.santarpino@libero.it

The Annals of Thoracic Surgery
|June 15, 2012
PubMed
Summary
This summary is machine-generated.

The sutureless Perceval S bioprosthesis offers easy implantation and reduced surgical trauma for aortic valve replacement. One-year results show satisfactory clinical and hemodynamic outcomes, making it a viable option for minimally invasive surgery.

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Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Engineering
  • Medical Device Technology

Background:

  • Sutureless aortic bioprostheses aim to simplify aortic valve replacement surgery.
  • Potential benefits include reduced ischemic time and surgical trauma.
  • This study evaluates a new sutureless bioprosthesis over one year.

Purpose of the Study:

  • To assess the clinical and echocardiographic outcomes of the Perceval S sutureless bioprosthesis.
  • To evaluate its safety and efficacy in patients undergoing aortic valve replacement.
  • To determine its suitability as an alternative for minimally invasive procedures.

Main Methods:

  • The Perceval S is a pericardial aortic prosthesis mounted on a super-elastic frame, implanted without sutures.
  • Data collected from 83 screened patients in a premarketing multicenter study (Cavalier Trial).
  • Clinical and echocardiographic data were analyzed at baseline, postoperatively, 6 months, and 1 year.

Main Results:

  • Mean aortic cross-clamp and implantation times were 43.8±20.8 and 8±3.8 minutes, respectively.
  • In-hospital mortality was 2.4%, with 6% pacemaker implantations.
  • At 1 year, patients showed improved New York Heart Association functional class (1.0±0.6) and stable transprosthetic gradients.

Conclusions:

  • The Perceval S bioprosthesis demonstrates favorable clinical and hemodynamic performance.
  • Its straightforward implantation technique is advantageous, particularly for minimally invasive aortic valve surgery.
  • Short aortic cross-clamp times contribute to minimized operative trauma.