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Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Factors Affecting Drug Biotransformation: Biological01:19

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Related Experiment Video

Updated: May 21, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Can small shifts in circadian phase affect performance?

Helen J Burgess1, Carlo S Legasto, Louis F Fogg

  • 1Biological Rhythms Research Laboratory, Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA. Helen_J_Burgess@rush.edu

Applied Ergonomics
|June 15, 2012
PubMed
Summary

Even small shifts in circadian timing, like those from daylight saving time, can significantly impair cognitive performance and reaction times. This highlights human sensitivity to disruptions in our internal body clocks.

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Published on: January 24, 2013

Area of Science:

  • Chronobiology
  • Sleep Science
  • Cognitive Performance

Background:

  • Circadian timing shifts are common due to factors like daylight saving time and weekend sleep variations.
  • While these shifts affect sleepiness, their impact on performance remains under investigation.

Purpose of the Study:

  • To investigate whether small shifts in circadian timing significantly affect cognitive performance.

Main Methods:

  • A retrospective analysis of 11 healthy adults with fixed sleep schedules.
  • Performance on the Psychomotor Vigilance Test (PVT) was assessed before bedtime and after waking.
  • Dim light melatonin onset (DLMO) was measured to mark circadian timing.

Main Results:

  • An average 1.1-hour shift from the optimal circadian phase angle was associated with significantly slower reaction times.
  • This performance decline was observed in mean, median, and fastest 10% reaction times.
  • The effects were significant both before bedtime and after waking (p < 0.05).

Conclusions:

  • Even minor shifts in circadian timing can measurably impair cognitive performance.
  • Humans appear sensitive to the performance impacts of commonly occurring circadian disruptions.