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Related Experiment Video

Updated: May 21, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Vascular tissue engineering: the next generation.

Muriel A Cleary1, Erik Geiger, Conor Grady

  • 1Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, 10 Amistad Street, Amistad Building Room 301, New Haven, CT 06520, USA.

Trends in Molecular Medicine
|June 15, 2012
PubMed
Summary
This summary is machine-generated.

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Tissue-engineered vascular grafts (TEVGs) aim to overcome limitations of current treatments for vascular repair. Developing immunologically compatible, non-thrombogenic TEVGs is crucial for long-term success in bypass surgeries.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Vascular Surgery

Background:

  • Native vessels are the preferred choice for bypass surgery but are often unavailable or unsuitable.
  • Synthetic vascular grafts face limitations, especially in small-diameter applications, including thrombosis, infection, and graft failure.
  • Tissue-engineered vascular grafts (TEVGs) offer a promising alternative to overcome these challenges.

Purpose of the Study:

  • To develop an autologous tissue-engineered vascular graft (TEVG).
  • To create a TEVG that is immunologically compatible and non-thrombogenic.
  • To engineer a TEVG capable of growth, remodeling, and mimicking native vasculature.

Main Methods:

  • Research focuses on developing TEVGs that integrate seamlessly into the patient's circulatory system.

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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

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Related Experiment Videos

Last Updated: May 21, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
13:04

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
09:55

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

  • Investigating methods to ensure TEVGs possess appropriate vasoreactivity and biomechanical properties.
  • Exploring strategies for long-term patency and functional integration of TEVGs.

    • Main Results:

    • (No specific results mentioned in the abstract, focus is on the goal and pursuit of research)
    • (The abstract outlines the desired characteristics and research aims, not experimental outcomes)
    • (Focus remains on the pursuit of an ideal TEVG)

    Conclusions:

    • The development of TEVGs is a critical goal in tissue engineering for vascular reconstruction.
    • Achieving immunological compatibility, non-thrombogenicity, and regenerative capacity are key to successful TEVG implementation.
    • TEVGs hold the potential to significantly improve outcomes in coronary artery bypass (CABG) and peripheral bypass surgeries.