Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cutaneous Manifestations of Epstein-Barr Virus: A Unique Case of Gianotti-Crosti Syndrome.

Journal of cutaneous pathology·2026

Same author

Majocchi's Granuloma.

The New England journal of medicine·2026

Same author

Establishing dermatopathology encyclopedia DermpathNet with Artificial Intelligence-Based Workflow.

Scientific data·2026

Same author

Lichen planopilaris in children: Clinical characteristics, comorbidities, and treatment outcomes in a single-center case series.

JAAD case reports·2026

Same author

Nicholas A. Soter, MD (1939-2025).

Journal of the American Academy of Dermatology·2025

Same author

Statement from the frontal fibrosing alopecia international expert alliance: SOFFIA 2024.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025

Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026

Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026

Same journal

Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

The Journal of investigative dermatology·2026

Same journal

Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment.

The Journal of investigative dermatology·2026

Same journal

The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue.

The Journal of investigative dermatology·2026

Same journal

Impact of Online vs In-Person Management of Atopic Dermatitis on Quality of Life and Access to Care: A Randomized Controlled Trial.

The Journal of investigative dermatology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 21, 2026

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

Engineering a new mouse model for vitiligo.

Prashiela Manga¹, Seth J Orlow

¹The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA.

The Journal of Investigative Dermatology

|June 15, 2012

Summary

This summary is machine-generated.

Researchers developed a new mouse model for vitiligo by overexpressing Kit ligand, enabling the study of autoimmune responses against interfollicular melanocytes, crucial for therapy development.

More Related Videos

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Published on: June 29, 2022

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

Related Experiment Videos

Last Updated: May 21, 2026

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Published on: June 29, 2022

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

Area of Science:

Immunology
Dermatology
Genetics

Background:

Vitiligo pathogenesis is not fully understood, with autoimmune responses playing a key role.
Current animal models are limited because mice lack the interfollicular melanocytes targeted in vitiligo.

Purpose of the Study:

To develop a novel mouse model that recapitulates key features of human vitiligo.
To facilitate the study of autoimmune mechanisms targeting interfollicular melanocytes.

Main Methods:

Overexpression of Kit ligand to retain interfollicular melanocytes in mice.
Transplantation of melanocyte-targeting CD8+ T cells to initiate an immune response.

Main Results:

Successfully created a mouse model with retained interfollicular melanocytes.
Demonstrated the initiation of an immune response against these melanocytes.

Conclusions:

This new model provides a valuable platform for investigating vitiligo.
It will aid in understanding autoimmune vitiligo and developing new therapies.