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Updated: May 21, 2026

Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography
Published on: July 6, 2015
Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation
1Institute of Hypertension, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China. yangtianxin@mail.sysu.edu.cn
Abstract:
Prostaglandin E(2) (PGE(2)) is a major prostanoid with a wide variety of biological activities. PGE(2) can influence blood pressure (BP) both positively and negatively. In particular, centrally administered PGE(2) induces hypertension whereas systemic administration of PGE(2) produces a hypotensive effect. These physiologically opposing effects are generated by the existence of multiple EP receptors, namely EP(1-4), which are G protein-coupled receptors with distinct signaling properties. This review highlights the distinct roles of PGE(2) in BP regulation and the involvement of specific EP receptor subtypes.
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