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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Related Experiment Video

Updated: May 21, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Notch2 and immune function.

Mamiko Sakata-Yanagimoto1, Shigeru Chiba

  • 1Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Current Topics in Microbiology and Immunology
|June 15, 2012
PubMed
Summary
This summary is machine-generated.

The Notch2 protein plays critical roles in immune cell development and function, influencing B cells, dendritic cells, and T cells. Aberrant Notch2 signaling is linked to immune cell transformations and diseases like leukemia and lymphoma.

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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

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Last Updated: May 21, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Notch2 is widely expressed across hematolymphoid lineages, indicating diverse functional roles.
  • Its involvement spans immune cell differentiation, development, and function, particularly in splenic and intestinal immunity.
  • Notch2 regulates key processes such as B cell development, dendritic cell differentiation, and T cell responses.

Purpose of the Study:

  • To elucidate the multifaceted roles of Notch2 in immune cell development and function.
  • To explore the implications of Notch2 dysregulation in immune system disorders.
  • To highlight the significance of Notch2 in maintaining immune homeostasis and its link to oncogenesis.

Main Methods:

  • Review of existing literature on Notch2 expression and function in immune cells.
  • Analysis of genetic studies investigating Notch2 mutations in hematological malignancies.
  • Integration of data from various immunological and cellular biology research.

Main Results:

  • Notch2 is essential for the development of splenic marginal zone B cells and differentiation of splenic dendritic cells.
  • It regulates mast cell and a subset of dendritic cell populations in the intestine.
  • Notch2 influences helper T cell divergence and cytotoxic T cell activation.
  • Both loss-of-function (inactivating mutations) and gain-of-function (activating mutations) of Notch2 are implicated in immune cell transformation.

Conclusions:

  • Notch2 is a critical regulator of immune cell development, differentiation, and function across multiple lineages.
  • Abnormalities in Notch2 signaling are associated with significant immune system pathologies, including chronic myelomonocytic leukemia and mature B cell lymphomas.
  • Understanding Notch2's role is crucial for deciphering immune cell development and identifying therapeutic targets for related cancers.