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Piracetam for fetal distress in labour
G Justus Hofmeyr1, Regina Kulier
1Department of Obstetrics and Gynaecology, East London Hospital Complex, University of the Witwatersrand, University of FortHare, Eastern Cape Department of Health, East London, South Africa. justhof@gmail.com.
Background:
Piracetam is thought to promote the metabolism of brain cells when they are hypoxic. It has been used to prevent adverse effects of fetal distress.
Objectives:
The objective of this review was to assess the effects of piracetam for suspected fetal distress in labour on method of delivery and perinatal morbidity.
Search Methods:
We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (15 February 2012).
Selection Criteria:
Randomised trials of piracetam compared with placebo or no treatment for suspected fetal distress in labour.
Data Collection And Analysis:
Both review authors assessed eligibility and trial quality.
Main Results:
One study of 96 women was included. Piracetam compared with placebo was associated with a trend to reduced need for caesarean section (risk ratio 0.57, 95% confidence interval 0.32 to 1.03). There were no statistically significant differences between the piracetam and placebo group for neonatal morbidity (measured by neonatal respiratory distress) or Apgar score.
Authors' Conclusions:
There is not enough evidence to evaluate the use of piracetam for fetal distress in labour.
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