Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of Large-Scale Adsorption Process Parameters Using Two-Mechanism Langmuir Constants.

Pharmaceutical research·2026
Same author

Explaining the underlying causes of different tabletability classifications of binary mixtures.

Journal of pharmaceutical sciences·2026
Same author

Chewable Tablets for Precise Unit Dosing of Animals.

Journal of pharmaceutical innovation·2026
Same author

Comparing the applicability of mixing rules to predict the tensile strength of compacted mixtures.

Journal of pharmaceutical sciences·2025
Same author

Interaction-Based Model to Predict Tensile Strength of Compacted Mixtures from Individual Component Data.

Molecular pharmaceutics·2025
Same author

Simultaneous XRD-DSC identifies correct drug-polymer solubility and miscibility for enantiotropic solid forms.

Journal of pharmaceutical sciences·2024

Related Experiment Video

Updated: May 21, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Characterizing compaction-induced thermodynamic changes in a common pharmaceutical excipient.

Dale Eric Wurster1, Ira S Buckner

  • 1College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA. wurster@uiowa.edu

Journal of Pharmaceutical Sciences
|June 15, 2012
PubMed
Summary

Compression of anhydrous lactose increases its energy state, likely due to residual strain. Compression calorimetry and heat of solution measurements confirmed this energy increase, showing excellent agreement.

More Related Videos

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing
09:39

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing

Published on: June 28, 2024

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Related Experiment Videos

Last Updated: May 21, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing
09:39

Characterizing Dissipative Elastic Metamaterials Produced by Additive Manufacturing

Published on: June 28, 2024

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Physical Chemistry

Background:

  • Pharmaceutical excipients like anhydrous lactose undergo significant physical changes during tablet compression.
  • Understanding energy changes during compaction is crucial for predicting tablet properties and stability.

Purpose of the Study:

  • To quantify the energy changes in anhydrous lactose during compression and decompression.
  • To investigate the nature of the energy increase using complementary techniques.

Main Methods:

  • Compression calorimetry was used to measure work, heat, and internal energy changes.
  • Heat of solution measurements were performed to independently assess compaction energy.
  • Specific volume and specific surface area analyses were conducted.

Main Results:

  • Both compression calorimetry (0.94 J/g) and heat of solution measurements (0.91 J/g) indicated an increase in anhydrous lactose's energy state.
  • Excellent agreement was observed between the two independent methods.
  • The stored energy is primarily attributed to residual strain within compacted particles.

Conclusions:

  • Compression calorimetry is a valid method for measuring energy changes in pharmaceutical excipients.
  • Compaction of anhydrous lactose leads to stored energy, mainly in the form of residual strain.
  • These findings have implications for powder compaction behavior and tablet formulation.