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Updated: May 21, 2026
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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Molar pregnancy in adolescents
Antônio Braga1, Whitfield B Growdon, Marilyn Bernstein
1Trophoblastic Disease Center, University Hospital Antonio Pedro at Fluminense Federal University, Niteroi, Brazil.
The Journal of Reproductive Medicine
|June 16, 2012
Summary
Adolescents with hydatidiform mole (HM) often present with vaginal bleeding and a higher rate of complete mole. Despite this, young women show a significantly decreased risk of developing gestational trophoblastic neoplasia (GTN).
Area of Science:
- Reproductive Endocrinology
- Gynecology
- Maternal-Fetal Medicine
Background:
- Hydatidiform mole (HM) is a gestational trophoblastic disease.
- Adolescent pregnancies present unique clinical considerations.
- Understanding HM presentation and outcomes in young women is crucial for appropriate management.
Purpose of the Study:
- To characterize the clinical presentation of hydatidiform mole (HM) in women under 20 years old.
- To compare clinical factors and outcomes of HM in adolescents versus adults.
- To identify if adolescent age influences the risk of developing gestational trophoblastic neoplasia (GTN).
Main Methods:
- Retrospective analysis of 1,494 women with HM from 1970-2009.
- Stratification of patients by age (<20 years for adolescents).
- Analysis of presenting signs, molar histology, and GTN development using logistic regression.
Main Results:
- Adolescents (14.7%) had a higher incidence of complete mole (86% vs. 75%).
- No difference in gestational age or hCG levels at diagnosis between groups.
- Multivariable analysis revealed adolescent age was associated with a decreased risk of GTN (HR 0.67).
Conclusions:
- Adolescents represent a significant portion of HM cases, commonly presenting with vaginal bleeding.
- While complete mole is more frequent in adolescents, they exhibit a reduced risk of GTN.
- Maternal age is an independent factor influencing GTN risk in HM patients.
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