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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Association between tuberculosis and atopy: role of the CD14-159C/T polymorphism.
A Baççioğlu Kavut1, F Kalpaklioğlu, E Birben
1Department of Clinical Immunology and Allergy, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
Summary
Increased tuberculosis exposure may influence asthma development in atopic individuals. The CD14-159C/T gene variant impacts eosinophil levels, particularly with higher tuberculosis exposure in allergy patients.
Area of Science:
- Immunology
- Genetics
- Environmental Health
Background:
- Allergic hypersensitivity arises from genetic and environmental interactions.
- Microbial product exposure levels can influence atopy and genetic predispositions.
Purpose of the Study:
- To investigate the impact of Mycobacterium tuberculosis (tuberculosis) exposure on atopic patients.
- To analyze the association between tuberculosis exposure, genetic factors, and atopy.
Main Methods:
- CD14-159C/T genotyping was performed on 118 atopic patients and 62 healthy controls.
- Data collected included lifestyle, tuberculosis exposure, vaccination, allergy tests, and blood biomarkers (sCD14, IFN-y, IgE, eosinophils).
- A tuberculosis exposure score was calculated.
Main Results:
- No significant differences in atopic phenotypes or key biomarkers were found between high/low tuberculosis exposure groups based on CD14 genotypes.
- Asthma frequency was higher in atopic patients with high tuberculosis exposure, independent of CD14 genotype.
- Elevated blood eosinophil counts were observed in atopic patients with high tuberculosis exposure and specific CD14 genotypes (CC+CT).
Conclusions:
- The C allele of the CD14-159C/T polymorphism influences eosinophil levels in atopic patients with significant tuberculosis exposure.
- The extent of tuberculosis exposure may play a role in modifying asthma development among atopic individuals.
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