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Updated: May 21, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
Low levels of knowledge and preventive practices regarding vertical hepatitis B transmission among perinatal nurses
Stephanie D Chao1, Chrissy M Cheung, Elizabeth J Yang
1Department of Surgery, Stanford Hospital and Clinics, Stanford, CA, USA.
Objective:
To evaluate current levels of hepatitis-B-related knowledge and clinical practice among perinatal nurses.
Design:
Cross-sectional study.
Setting:
Santa Clara County, California, home to one of the largest U.S. populations at risk of perinatal hepatitis B transmission.
Participants:
Perinatal nurses (N = 518) from eight birthing hospitals.
Methods:
In 2008-2010, nurses completed a baseline survey evaluating existing hepatitis-B-related knowledge and preventive clinical practices, participated in an educational seminar, received instructional materials about hepatitis B, and completed a follow-up knowledge survey.
Results:
Eighty percent of perinatal nurses had provided health care to a pregnant woman with chronic hepatitis B, but only 51% routinely provided patients with educational information about hepatitis B. While 75% routinely informed patients about effective methods to prevent mother-to-child transmission, only a small minority (17-34%) educated infected women about standard recommendations for protecting themselves and household members. One fourth or fewer nurses correctly answered most questions about hepatitis B prevalence, risks, and symptoms. After the educational seminar, knowledge increased statistically significantly.
Conclusion:
Existing knowledge about hepatitis B is limited, and nationally recommended preventive clinical practices are commonly overlooked by perinatal nurses. This lack of knowledge and preventive care represents a noteworthy gap and an opportunity for targeted training and education to improve perinatal hepatitis B prevention and medical management of infected mothers.
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