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Updated: May 21, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Study of the lanthanide-catalyzed, aqueous, asymmetric Mukaiyama aldol reaction
Yujiang Mei1, Derek J Averill, Matthew J Allen
1Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
Abstract:
The development of efficient methods for the asymmetric Mukaiyama aldol reaction in aqueous solution has received great attention. We have developed a new series of chiral lanthanide-containing complexes that produce Mukaiyama aldol products with outstanding enantioselectivities. In this paper, we describe an optimized ligand synthesis, trends in stereoselectivity that result from changing lanthanide ions, and an exploration of substrate scope that includes aromatic and aliphatic aldehydes and silyl enol ethers derived from aromatic and aliphatic ketones.
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