Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Knee Joint

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...

Development of the Limb Synovial Joints

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...

Ankle Joint

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Recovery Plateaus and Ceiling Effects of Commonly Used Patient-Reported Outcome Measures Following Primary Total Knee Arthroplasty.

The Journal of arthroplasty·2026

Same author

Baseline Characteristics Explain Sex Differences in Primary Total Knee Arthroplasty Outcomes: A Prospective Multicenter Study With 4-Year Follow-Up.

The Journal of arthroplasty·2026

Same author

The management of cartilage defects of the knee and injection therapy - A collaborative and retrospective study.

The Knee·2025

Same author

The number of fractures of the distal radius in older adult patients will almost double by 2040 : prediction modelling using national data from Scotland.

The bone & joint journal·2025

Same author

Are Currently Available Joint-Specific Patient-Reported Outcome Measures Fit for Purpose to Assess the Outcome of Knee Arthroplasty?

Journal of clinical medicine·2025

Same author

Operative management of displaced fractures of the distal radius is associated with improved function but not in older adults : systematic review and meta-analysis of randomized controlled trials.

Bone & joint open·2025

Search research articles

Related Experiment Video

Updated: May 21, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Lower limb joint replacement in rheumatoid arthritis.

Nicholas D Clement¹, Stephen J Breusch, Leela C Biant

¹Orthopaedic Research Fellow, Royal Infirmary of Edinburgh, Little France EH16 4SA, UK. nickclement@doctors.org.uk

Journal of Orthopaedic Surgery and Research

|June 16, 2012

Summary

Optimizing rheumatoid arthritis patients for lower limb arthroplasty requires a multidisciplinary approach. While cemented implants and continued methotrexate use are beneficial, biologic agents should be stopped pre-operatively to minimize infection risks.

More Related Videos

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

Related Experiment Videos

Last Updated: May 21, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

Area of Science:

Orthopedic Surgery
Rheumatology

Background:

Limited literature exists on peri-operative and surgical management for rheumatoid arthritis (RA) patients undergoing lower limb arthroplasty.
This review synthesizes key factors for managing RA patients undergoing major lower limb arthroplasty.

Purpose of the Study:

To summarize peri-operative management strategies for rheumatoid arthritis patients undergoing lower limb arthroplasty.
To provide evidence-based recommendations for optimizing surgical outcomes in this patient population.

Main Methods:

A literature search was conducted using PubMed.
Search terms included: 'rheumatoid', 'replacement', 'arthroplasty', and 'outcome'.

Main Results:

Pre-operative optimization via a multidisciplinary team is crucial.
Methotrexate can be continued; biologic agents should be stopped due to infection risk.
Cemented total hip replacement (THR) and total knee replacement (TKR) show superior survival rates.
Total ankle replacement outcomes are inferior to THR and TKR, with slower rehabilitation and functional outcomes in RA patients.

Conclusions:

Multidisciplinary team management is key for optimizing outcomes in RA patients undergoing lower limb arthroplasty.
Patients must be informed of increased infection and periprosthetic fracture risks.
Cemented THR and TKR, and potentially cruciate-sacrificing TKR with patella resurfacing, are recommended.