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G-protein coupled receptor resensitization-appreciating the balancing act of receptor function

Maradumane L Mohan1, Neelakantan T Vasudevan, Manveen K Gupta

  • 1Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195. prasads2@ccf.org.

Current Molecular Pharmacology
|June 16, 2012
PubMed
Summary

G-protein coupled receptors (GPCRs) regulate cellular functions through activation, desensitization, and resensitization. This review emphasizes resensitization as a critical, dynamic process in GPCR regulation, often overlooked in drug discovery.

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