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Automated 90Sr Separation and Preconcentration in a Lab-on-Valve System at Ppq Level

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Radioarsenic from a portable (72)Se/(72)As generator: a current perspective.

B Ballard¹, F M Nortier, E R Birnbaum

¹Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Current Radiopharmaceuticals

|June 16, 2012

Summary

This summary is machine-generated.

A novel Selenium-72/Arsenic-72 generator system offers a practical solution for producing longer-lived Arsenic-72 positron emission tomography (PET) radioisotopes at the point-of-care, enhancing radiotracer availability for slower biological processes.

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Area of Science:

Nuclear medicine
Radiochemistry
Biomolecular imaging

Background:

Positron emission tomography (PET) requires longer-lived positron emitters for imaging slower biological processes.
Radionuclide production, labeling chemistry, and point-of-care availability limit radioisotope selection for PET.
The Selenium-72/Arsenic-72 (72Se/72As) pair presents a promising generator system for a longer-lived PET isotope.

Purpose of the Study:

To review available generator concepts for the 72Se/72As system.
To outline current methodologies for introducing radioarsenic into biomolecules.
To address the need for practical, on-site PET radiotracer production.

Main Methods:

Review of existing 72Se/72As generator designs.
Description of chemical strategies leveraging Se(IV)/Se(VI) and As(III)/As(V) redox states.
Overview of radioarsenic labeling techniques for biomolecules.

Main Results:

The 72Se/72As generator system provides a viable method for producing 72As (half-life 26 h) from 72Se (half-life 8.5 d).
Various generator concepts have been developed exploiting selenium and arsenic redox chemistry.
Established methods exist for incorporating radioarsenic into target biomolecules.

Conclusions:

The 72Se/72As generator system enhances the clinical availability of a longer-lived PET radioisotope.
This system addresses the limitations of radioisotope production and on-site radiotracer generation.
Further development of arsenic labeling chemistry will expand its utility in molecular imaging.