Nuclear GPS for interchromosomal clustering
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Updated: May 21, 2026

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
Published on: January 25, 2020
1Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Abstract:
Nuclear architecture and the relative position of a gene can play roles in the regulation of its expression. In this issue of Developmental Cell, Brickner et al. (2012) analyze nuclear global positioning of genes and reveal that the Put3 transcription factor functions with cis-encoded DNA elements and nuclear pore complexes to regulate interchromosomal gene clustering.
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