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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Ascites01:19

Ascites

DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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Updated: May 21, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

[Lipedema: a misdiagnosed entity].

S Vignes1

  • 1Unité de lymphologie, centre national de référence des maladies vasculaires rares (lymphœdèmes primaires), hôpital Cognacq-Jay, 15, rue Eugène-Millon, 75015 Paris, France. stephane.vignes@cognacq-jay.fr

Journal Des Maladies Vasculaires
|June 16, 2012
PubMed
Summary
This summary is machine-generated.

Lipedema, a fat disorder in women, causes leg enlargement and pain, often mistaken for lymphedema. Liposuction can improve symptoms and quality of life.

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Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
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Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

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Area of Science:

  • Endocrinology
  • Vascular Medicine
  • Dermatology

Context:

  • Lipedema is a common yet frequently misdiagnosed adipose tissue disorder.
  • It predominantly affects obese women, presenting as bilateral leg enlargement from hip to ankle.
  • Disease onset typically occurs around puberty, causing significant cosmetic distress and physical discomfort.

Purpose:

  • To differentiate lipedema from primary lymphedema.
  • To describe the clinical characteristics, diagnostic considerations, and management options for lipedema.
  • To evaluate the impact of liposuction on lipedema symptoms and quality of life.

Summary:

  • Lipedema involves abnormal subcutaneous fat deposition, often with mild edema sparing the feet, and is associated with pain, tenderness, and easy bruising.
  • Diagnostic imaging is generally not indicated unless the presentation is atypical.
  • Long-term complications can include lipo-lymphedema and cellulitis.

Impact:

  • Current management includes weight loss, psychological support, and compression therapy, with variable results.
  • Liposuction, particularly tumescent liposuction, shows promise in reducing edema, pain, and bruising, and improving cosmetic appearance.
  • Effective lipedema management, including surgical options, can significantly enhance patients' quality of life.