Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 21, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Active axial stress in mouse aorta.

A Agianniotis1, A Rachev, N Stergiopulos

  • 1Laboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. aristotelis.agianniotis@epfl.ch

Journal of Biomechanics
|June 16, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In silico validation of non-invasive arterial compliance estimation and potential determinants of its variability.

Physiological research·2025
Same author

Anti-apoA-1 auto-antibodies increase mouse atherosclerotic plaque vulnerability, myocardial necrosis and mortality triggering TLR2 and TLR4.

Thrombosis and haemostasis·2015
Same author

Brachial artery waveforms for automatic blood pressure measurement.

Journal of biomechanics·2012
Same author

A method for the quantification of the pressure dependent 3D collagen configuration in the arterial adventitia.

Journal of structural biology·2012
Same author

Impact of aortic grafts on arterial pressure: a computational fluid dynamics study.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2011
Same author

Experimental investigation of collagen waviness and orientation in the arterial adventitia using confocal laser scanning microscopy.

Biomechanics and modeling in mechanobiology·2011

Active axial stress in mouse aorta smooth muscle is independent of pressure but highly dependent on longitudinal stretch. Maximum stress occurs at a stretch ratio of 1.81, with a threshold of 1.56.

Area of Science:

  • Vascular mechanics
  • Biomedical engineering
  • Physiology

Background:

  • Vascular smooth muscle cells (VSMCs) generate active stress, contributing to vessel tone and function.
  • Understanding active stress development is crucial for modeling vascular rheology and disease.
  • Previous studies focused on circumferential stress, leaving axial stress less characterized.

Purpose of the Study:

  • To investigate the development of active axial stress in mouse aorta.
  • To determine the relationship between active axial stress and physiological loads (pressure and stretch).
  • To compare axial active stress with circumferential active stress.

Main Methods:

  • Controlled mechanical loading of isolated mouse aortic segments.
  • Stimulation of smooth muscle cells to induce contraction.

More Related Videos

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

Minimally Invasive Transverse Aortic Constriction in Mice
07:40

Minimally Invasive Transverse Aortic Constriction in Mice

Published on: March 14, 2017

Related Experiment Videos

Last Updated: May 21, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

Minimally Invasive Transverse Aortic Constriction in Mice
07:40

Minimally Invasive Transverse Aortic Constriction in Mice

Published on: March 14, 2017

  • Measurement of active axial stress under varying pressure and longitudinal stretch.
  • Mathematical fitting of experimental data to derive stress-stretch relationships.

    • Main Results:

    • Active axial stress is largely independent of transmural pressure.
    • Active axial stress exhibits a non-monotonic dependence on the longitudinal stretch ratio.
    • Maximum active axial stress is achieved at a longitudinal stretch ratio of 1.81.
    • A minimum longitudinal stretch ratio of 1.56 is required to generate active stress.
    • Active axial stress is found to be lower in magnitude than active circumferential stress.

    Conclusions:

    • The longitudinal stretch ratio is the primary determinant of active axial stress in the aorta.
    • The findings provide critical data for developing more accurate biomechanical models of the aorta.
    • Further research is needed on diverse arterial types and conditions to refine vascular rheology models.