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Related Experiment Videos

Competitive interactions between neurons making axosomatic contacts in the leech.

X N Gu1, K J Muller

  • 1Department of Physiology and Biophysics, University of Miami School of Medicine, Florida 33136.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 1, 1990
PubMed
Summary

Leech nociceptive neurons normally avoid their own ganglion. Denervation, not injury, triggers these neurons to sprout and wrap targets within their own ganglion, overcoming normal inhibition.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Lateral nociceptive (N) neurons in leeches typically innervate somata in adjacent ganglia.
  • These neurons normally do not innervate somata within their own ganglion.

Purpose of the Study:

  • To investigate the factors that regulate the sprouting and target-wrapping behavior of leech nociceptive neurons within their own ganglion.
  • To determine whether denervation or direct injury triggers sprouting in the leech nervous system.

Main Methods:

  • Adult leeches were used to study neuronal regeneration and sprouting.
  • Nerve cord isolation was performed to induce sprouting within the neuron's own ganglion.
  • Focal lesions and protease injections were used to denervate target cells without directly injuring the nociceptive neurons.

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Main Results:

  • Isolation of a ganglion by cutting the nerve cord induced sprouting of lateral N neurons within their own ganglion.
  • Denervation of target somata, achieved through focal lesions or protease injections into other neurons, also led to sprouting within 2-4 months.
  • Cutting the axons of the lateral N cell itself resulted in minimal sprouting within the ganglion without concurrent denervation.

Conclusions:

  • Denervation of target somata is the primary factor inducing sprouting of lateral N neurons within their own ganglion, rather than direct injury to the neuron.
  • Lateral N neurons possess the intrinsic capacity to innervate homologous targets within their own ganglion.
  • Axonal wrappings from adjacent ganglia normally inhibit N neurons from innervating targets in their home ganglion.