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Relationship between myeloid-related protein 8/14 and survival of Chinese peritoneal dialysis patients
Peter Yam-Kau Poon1, Cheuk-Chun Szeto, Bonnie Ching-Ha Kwan
1Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Background:
Myeloid-related protein 8/14 (MRP8/14) is released by cells of myeloid lineage upon inflammatory challenges. Experimental data suggested that MRP8/14 is important in the initiation and progression of inflammation and cardiovascular diseases. We examined the relation between serum MRP8/14 level and cardiovascular disease in Chinese peritoneal dialysis (PD) patients.
Methods:
We studied 102 new PD patients (58 males, mean age 57.3 ± 11.9 years). Baseline serum MRP8/14 was determined and grouped to quartiles for analysis. All patients were then followed for an average of 23.9 ± 6.9 months.
Results:
There was a trend of lower 3-year cardiovascular event-free survival for patient quartiles with high serum MRP8/14 levels (log-rank test, p = 0.064). The 3-year actuarial survival was significantly lower for quartile groups with higher MRP8/14 levels (96.0, 94.7, 72.9, and 62.5% for quartiles 1-4, respectively, p = 0.003). Cox regression analysis showed that serum MRP8/14 level and Kt/V were independent predictors of actuarial survival; in this model, every 1 µg/ml increase in serum MRP8/14 level confers a 25.1% increase in risk of death (95% confidence interval, 1.3-54.4%, p = 0.037). There was no significant difference in technique survival between the MRP8/14 quartile groups.
Conclusion:
A high baseline serum MRP8/14 level was associated with a lower actuarial survival in Chinese PD patients. The pathogenic role of MRP8/14 in the cardiovascular disease of PD patients needs further investigation.
Insights
High serum myeloid-related protein 8/14 (MRP8/14) levels are linked to reduced survival in Chinese peritoneal dialysis patients. Further research is needed to understand MRP8/14
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Inflammation Research
Background:
- Myeloid-related protein 8/14 (MRP8/14) is a key inflammatory marker released by myeloid cells.
- Experimental studies suggest MRP8/14's role in inflammation and cardiovascular disease (CVD) pathogenesis.
- The association between serum MRP8/14 and CVD in Chinese peritoneal dialysis (PD) patients remains unclear.
Purpose of the Study:
- To investigate the relationship between baseline serum MRP8/14 levels and cardiovascular disease outcomes in Chinese PD patients.
- To determine if serum MRP8/14 is an independent predictor of survival in PD patients.
Main Methods:
- A cohort of 102 new Chinese PD patients was studied.
- Baseline serum MRP8/14 levels were measured and categorized into quartiles.
- Patients were followed for an average of 23.9 months to assess cardiovascular events and survival.
Main Results:
- Higher baseline serum MRP8/14 levels showed a trend towards lower 3-year cardiovascular event-free survival (p=0.064).
- Significantly lower 3-year actuarial survival rates were observed in higher MRP8/14 quartiles (p=0.003).
- Cox regression identified serum MRP8/14 level as an independent predictor of actuarial survival, with each 1 µg/ml increase conferring a 25.1% higher risk of death (p=0.037).
Conclusions:
- Elevated baseline serum MRP8/14 levels are associated with reduced actuarial survival in Chinese PD patients.
- Serum MRP8/14 may play a pathogenic role in cardiovascular disease among PD patients.
- Further investigation into the role of MRP8/14 in PD-related cardiovascular complications is warranted.
