Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Thrombectomy for Pediatric Large Vessel Occlusion Stroke With Mild Presenting Symptoms.

Neurology·2026

Same author

A comprehensive framework for automated segmentation of perivascular spaces in brain MRI with the nnU-Net.

Neuroradiology·2026

Same author

Idiopathic Pulmonary Fibrosis: An Overview.

British journal of hospital medicine (London, England : 2005)·2026

Same author

Safety Profile of Dimethyl Sulfoxide-Based Liquid Embolic Agents for Neurointerventional Procedures in Neonates, Infants, and Toddlers: A Cohort Study.

AJNR. American journal of neuroradiology·2026

Same author

Relationship Between Baseline Infarct and Clinical Outcome in Pediatric Large-Vessel Occlusion Ischemic Stroke.

Stroke (Hoboken, N.J.)·2026

Same author

WHO's category mistake.

Lancet (London, England)·2025

Search research articles

Related Experiment Video

Updated: May 21, 2026

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Diffusion tensor imaging to aid subgenual cingulum target selection for deep brain stimulation in depression.

Kartik D Bhatia¹, Luke Henderson, George Ramsey-Stewart

¹Department of Anatomy, University of Sydney, Camperdown, NSW, Australia. kartikdevbhatia@gmail.com

Stereotactic and Functional Neurosurgery

|June 16, 2012

Summary

Diffusion tensor imaging (DTI) offers a more precise method for selecting deep brain stimulation targets in the subgenual cingulate gyrus (Cg25) for depression. This advanced technique identifies significantly different target locations compared to standard MRI, potentially improving treatment outcomes.

More Related Videos

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

Related Experiment Videos

Last Updated: May 21, 2026

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

Area of Science:

Neuroimaging
Neurosurgery
Psychiatry

Background:

The subgenual cingulate gyrus (Cg25) is a key brain region implicated in depression and a primary target for deep brain stimulation.
Diffusion tensor imaging (DTI) visualizes white matter tracts, offering potential improvements in surgical target selection.

Purpose of the Study:

To compare the location of deep brain stimulation targets in Cg25 selected using DTI with those identified by standard T2-weighted MRI sequences.
To determine if DTI-based target selection, focusing on maximal tract crossover (isotropy), yields significantly different coordinates.

Main Methods:

Fifty-nine healthy adult volunteers underwent brain MRI, including T1, T2, and DTI sequences.
Deep brain stimulation targets were identified in both hemispheres using both T2 and DTI sequences.
Paired t-tests were used to analyze differences in target coordinates (x, y, z) between the two methods.

Main Results:

A statistically significant difference was observed in the mediolateral (x) and dorsoventral (z) coordinates of targets selected by DTI compared to T2 sequences (p < 0.001).
These findings indicate that DTI identifies distinct anatomical locations within Cg25.

Conclusions:

DTI-based target selection for deep brain stimulation in Cg25 results in significantly different locations compared to standard T2-based selection.
This DTI approach may enhance treatment efficacy for depression by accounting for individual white matter variability and optimizing target engagement.