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Updated: May 21, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Cycloartane triterpenes and ingol diterpenes isolated from Euphorbia neriifolia in a screening program for
Kazufumi Toume1, Takafumi Nakazawa, Tahmina Hoque
1Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Abstract:
In our screening program for natural products that increase death-receptor 5 expression, seven new cycloartane triterpenes, euphonerins A-G (1-7), and 3-O-acetyl-8-O-tigloylingol (8), a new ingol diterpene, were isolated from the MeOH extract of Euphorbia neriifolia leaves, together with 3,12-di-O-acetyl-8-O-tigloylingol (9), (24R)-cycloartane-3β,24,25-triol (10), and three known flavonols (11-13). The structures of 1-8 were elucidated by spectroscopic analysis. Among these compounds, 1-11 showed death-receptor 5 expression enhancing activity.
