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Related Concept Videos

Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

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Related Experiment Video

Updated: May 21, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Brucellar spondylodiscitis affecting non-contiguous spine levels.

D Mrabet1, H Mizouni, H Khiari

  • 1Department of Rheumatology, La Rabta Hospital, Tunis, Tunisia. mrabetdalila@yahoo.fr

BMJ Case Reports
|June 16, 2012
PubMed
Summary

Brucellosis can affect multiple spine levels, a rare presentation of brucellar spondylodiscitis. Early diagnosis using serological tests and MRI is crucial for timely treatment in endemic areas.

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Last Updated: May 21, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
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Area of Science:

  • Infectious Diseases
  • Musculoskeletal Disorders
  • Medical Imaging

Background:

  • Brucellosis is a zoonotic infection with diverse organ involvement.
  • The spine is the most frequent site of musculoskeletal brucellosis.
  • Multiple-level spinal involvement in brucellar spondylodiscitis is uncommon.

Observation:

  • A case report details a 56-year-old male shepherd with simultaneous cervical, thoracic, and lumbar spondylodiscitis.
  • Diagnosis was confirmed via a positive brucella-agglutination test and Magnetic Resonance Imaging (MRI).

Findings:

  • This case highlights a rare manifestation of brucellar spondylodiscitis involving multiple spinal regions.
  • Magnetic Resonance Imaging (MRI) aids in diagnosing spinal brucellosis.
  • Brucella-agglutination testing is a key diagnostic tool.

Implications:

  • Increased clinical suspicion for brucellar spondylodiscitis is vital, especially in endemic regions.
  • Brucellar spondylodiscitis should be considered in the differential diagnosis of prolonged spinal pain.
  • Wider use of screening serological tests for brucellosis is recommended in at-risk populations.