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Related Experiment Video

Updated: May 21, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Using the KEGG database resource.

Mao Tanabe¹, Minoru Kanehisa¹

¹Bioinformatics Center, Institute for Chemical Research, Kyoto University, Kyoto, Japan.

Current Protocols in Bioinformatics

|June 16, 2012

Summary

The Kyoto Encyclopedia of Genes and Genomes (KEGG) offers integrated bioinformatics data for understanding cellular and organismal functions. Protocols are described for utilizing KEGG's diverse resources, including genomic, chemical, and network information.

Area of Science:

Bioinformatics
Systems Biology
Genomics

Background:

The Kyoto Encyclopedia of Genes and Genomes (KEGG) is a comprehensive bioinformatics database.
It integrates genomic, chemical, and network information for biological research.
KEGG provides insights into cellular and organismal functions from multiple perspectives.

Purpose of the Study:

To describe protocols for effectively utilizing the KEGG database.
To highlight the diverse functionalities and data types within KEGG.
To enable users to leverage KEGG for comprehensive biological analysis.

Main Methods:

Utilizing KEGG PATHWAY, KEGG BRITE, and KEGG MODULE for molecular network analysis.
Employing KEGG DISEASE and KEGG DRUG for studying perturbed molecular networks.

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Accessing KEGG GENES and KEGG LIGAND for molecular building block information.

Leveraging KEGG ORTHOLOGY (KO) to link genomic data with molecular networks.

Main Results:

Detailed protocols are provided for accessing and analyzing various KEGG data modules.
The described methods facilitate the exploration of molecular interactions and cellular functions.
Users can effectively link genomic information to functional molecular networks.

Conclusions:

KEGG serves as a powerful, integrated resource for biological research.
The provided protocols enhance the utility of KEGG for diverse scientific inquiries.
Comprehensive understanding of cellular and organismal functions is achievable through KEGG's functionalities.