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06:21
Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
Acute myeloid leukemia presenting as obstructive jaundice
Binitha Rajeswari1, Anu Ninan, Sindhu Nair Prasannakumari
1Division of Pediatric Oncology, Regional Cancer Centre, Trivandrum, India. rbinitha@yahoo.co.in
Indian Pediatrics
|June 16, 2012
Summary
Jaundice is a rare initial sign in pediatric acute myeloid leukemia (AML). This report details two cases where AML caused obstructive jaundice, with poor prognosis for affected children.
Area of Science:
- Pediatric Oncology
- Hematology
- Gastroenterology
Background:
- Acute myeloid leukemia (AML) is a rare cancer in children.
- Jaundice is an uncommon presenting symptom in pediatric AML.
- Obstructive jaundice can result from various causes, including malignancy.
Observation:
- Two pediatric cases of acute myeloid leukemia (AML) presenting with obstructive jaundice are described.
- One case involved a malignant stricture of the common bile duct.
- The second case featured a granulocytic sarcoma obstructing the bile duct.
Findings:
- Pediatric AML can manifest with obstructive jaundice due to biliary tract infiltration or compression.
- Granulocytic sarcoma, a solid tumor manifestation of AML, can cause bile duct obstruction.
- Malignant strictures in the common bile duct can also be an AML presentation.
Implications:
- Early recognition of jaundice in pediatric AML is crucial for timely diagnosis and treatment.
- The presence of obstructive jaundice in pediatric AML is associated with a poor prognosis.
- This presentation highlights the diverse clinical manifestations of AML in children and the need for comprehensive diagnostic approaches.
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