Related Experiment Video
Updated: May 21, 2026

A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae
Published on: April 25, 2015
RegPrecise web services interface: programmatic access to the transcriptional regulatory interactions in bacteria
Pavel S Novichkov1, Thomas S Brettin, Elena S Novichkova
1Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. psnovichkov@lbl.org
A new web services application programming interface (API) provides programmatic access to the RegPrecise database, a key resource for microbial transcriptional regulation. This API facilitates efficient data retrieval for over 1400 regulogs across bacterial genomes.
Area of Science:
- Microbiology
- Bioinformatics
- Systems Biology
Background:
- The RegPrecise database is a core resource for microbial transcriptional regulation, housing information on regulogs derived from comparative genomics.
- Understanding transcriptional regulation is crucial for deciphering microbial gene expression and cellular functions.
Purpose of the Study:
- To develop a web services application programming interface (API) for programmatic access to the RegPrecise database.
- To enhance data accessibility and facilitate the utilization of curated regulatory interaction information.
Main Methods:
- Development of a comprehensive API with 14 web service resources.
- Integration of programmatic access to the RegPrecise database (version 2.0).
- Leveraging comparative genomics to reconstruct and store regulogs.
Main Results:
- The API provides efficient programmatic access to >1400 regulogs from >250 bacterial genomes.
- The RegPrecise database includes regulatory interactions involving transcription factors and RNA regulatory motifs.
- The data can serve as a basis for automatic annotation of regulatory interactions in new genomes.
Conclusions:
- The developed API significantly improves access to microbial transcriptional regulatory data.
- This resource supports research in microbial genomics and systems biology.
- The RegPrecise web services API is freely available, promoting wider scientific use.
More Related Videos
13:48Discovering CsgD Regulatory Targets in Salmonella Biofilm Using Chromatin Immunoprecipitation and High-Throughput Sequencing (ChIP-seq)
Published on: January 18, 2020
12:24DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
Published on: July 21, 2014
Related Concept Videos
Prokaryotic Transcriptional Activators and Repressors
Transcription of prokaryotic...
Prokaryotic Transcriptional Activators and Repressors
Transcription of prokaryotic...
Coordination of Gene Expression Processes in Bacteria
Global Regulatory Systems
Master Transcription Regulators
Cis-regulatory Sequences