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Updated: May 21, 2026
08:32
Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
Published on: February 17, 2023
Carbapenem-resistant enterobacteriaceae: an emerging problem in children
1Section of Pediatric Infectious Diseases, Department of Pediatrics, Rush University Medical Center, Rush Medical College, Chicago, Illinois, USA. Latania_Logan@rush.edu
Summary
Antibiotic resistance is a critical threat, especially carbapenem-resistant Enterobacteriaceae (CRE) in children. This review examines CRE infections in pediatric populations, covering epidemiology, risk factors, and treatment outcomes.
Area of Science:
- Infectious Diseases
- Microbiology
- Pediatric Medicine
Background:
- Antibiotic resistance in gram-negative bacteria is escalating globally.
- Carbapenem-resistant Enterobacteriaceae (CRE) pose a significant threat due to resistance to multiple antibiotic classes.
- CRE infections are linked to high morbidity and mortality, increasingly affecting vulnerable pediatric populations.
Purpose of the Study:
- To provide an overview of carbapenem-resistant Enterobacteriaceae (CRE).
- To focus on CRE infections specifically within the pediatric population.
- To summarize current data on CRE in children, including epidemiology, clinical features, resistance mechanisms, risk factors, and treatment.
Main Methods:
- This is a review article.
- It synthesizes existing literature and data on CRE infections in children.
- Focuses on epidemiological trends, clinical presentations, and therapeutic strategies.
Main Results:
- CRE infections in children are associated with severe illness and poor outcomes.
- Common carbapenemase types and risk factors in pediatric patients are identified.
- Data highlights the challenges in treating multi-drug resistant infections in this age group.
Conclusions:
- CRE represents a growing challenge in pediatric infectious diseases.
- Understanding the epidemiology and clinical characteristics of CRE in children is crucial for effective management.
- Further research and targeted interventions are needed to combat CRE in pediatric populations.
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