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Otitis interna induced by Cryptococcus neoformans var. grubii in a cat.
J Paulin1, M Morshed, A G Armién
1Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Ave, St Paul, MN 55108, USA.
Veterinary Pathology
|June 16, 2012
Summary
A domestic shorthair cat developed acute vestibular disease due to Cryptococcus neoformans var. grubii infection. The fungus caused granulomatous inflammation in the inner ear, impairing hearing and balance.
Area of Science:
- Veterinary Mycology
- Comparative Pathology
Background:
- Cryptococcus neoformans var. grubii is an opportunistic fungal pathogen.
- Otitis interna can lead to vestibular dysfunction in animals.
Observation:
- A 7-year-old domestic shorthair cat presented with acute vestibular disease.
- Necropsy revealed bilateral otitis interna.
Findings:
- Histopathology confirmed granulomatous inflammation with yeasts in the inner ear structures (vestibule, cochlea, semicircular canals).
- Inflammation and yeasts obstructed inner ear spaces, disrupting key sensory components.
- The infection was likely hematogenously disseminated.
Implications:
- This case highlights Cryptococcus neoformans var. grubii as a cause of otitis interna and vestibular disease in cats.
- Understanding fungal dissemination routes is crucial for veterinary diagnostics and treatment.
