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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: May 21, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Stem cell niches for skin regeneration.

Victor W Wong1, Benjamin Levi, Jayakumar Rajadas

  • 1Department of Surgery, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.

International Journal of Biomaterials
|June 16, 2012
PubMed
Summary

Stem cell therapies hold promise for skin regeneration. Understanding the stem cell niche is crucial for developing effective biomaterials that mimic these environments for tissue repair.

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Last Updated: May 21, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

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Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
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Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Published on: April 18, 2019

Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Dermatology

Background:

  • Stem cell-based therapies show significant potential for skin regeneration after injury or disease.
  • Functional stem cell units exist across all human skin layers.
  • The stem cell niche, comprising microenvironmental cues, is key to skin's regenerative capacity.

Purpose of the Study:

  • To investigate stem cells within specific skin niches as models for regeneration.
  • To highlight the importance of understanding niche biology for skin engineering.
  • To propose biomaterial strategies that recapitulate skin microenvironments.

Main Methods:

  • Investigation of stem cells in hair follicle bulge, interfollicular epidermis, dermal papillae, and perivascular space.
  • Analysis of physical and chemical microenvironmental cues within the stem cell niche.
  • Conceptualization of biomaterial systems to mimic native skin niches.

Main Results:

  • Stem cells in various skin locations (hair follicle bulge, epidermis, dermis) are viable models for niche-driven regeneration.
  • The intricate molecular and biologic features of stem cell niches are critical for effective skin engineering.
  • Biomaterial systems recapitulating these niches are essential for successful skin repair.

Conclusions:

  • Stem cell strategies for skin regeneration must integrate knowledge of niche-specific features.
  • Innovative biomaterials that mimic the stem cell niche are vital for advancing progenitor cell-mediated skin repair.
  • Understanding the stem cell niche is fundamental to unlocking the full potential of skin regeneration therapies.