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Norfloxacin-induced hypoglycemia and urticaria
1Department of Medicine, Pramukhswami Medical College, Karamsad, India. dram1967@rediffmail.com
Indian Journal of Pharmacology
|June 16, 2012
Summary
Fluoroquinolone antibiotics can rarely cause hypoglycemia, a dangerous drop in blood sugar. This case highlights norfloxacin-induced hypoglycemia and urticaria in a non-diabetic patient, urging clinical awareness.
Area of Science:
- Pharmacology
- Endocrinology
- Adverse Drug Reactions
Background:
- Fluoroquinolones are broad-spectrum antibiotics with known adverse effects.
- Hypoglycemia is a rare but serious adverse drug reaction associated with fluoroquinolones, particularly in elderly patients with type 2 diabetes on sulfonylureas.
- The precise mechanism involves potential blockage of Adenosine 5'-Triphosphate (ATP)-sensitive potassium channels in pancreatic beta-cells.
Purpose of the Study:
- To report a case of norfloxacin-induced hypoglycemia and urticaria in a middle-aged, non-diabetic patient.
- To increase awareness among clinicians regarding this potential adverse drug reaction.
Main Methods:
- Case report presentation.
- Review of existing literature on fluoroquinolone-induced hypoglycemia.
Main Results:
- The patient experienced hypoglycemia and urticaria during norfloxacin therapy.
- This adverse event occurred in a non-diabetic individual, expanding the known patient profile.
Conclusions:
- Norfloxacin can induce hypoglycemia and urticaria as adverse drug reactions.
- Clinicians must remain vigilant for these potential side effects in patients undergoing norfloxacin treatment, irrespective of diabetic status.
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